Day: April 27, 2018

literature review
CPP/Bioportide technologies have the capcity to reach intracellular sites that may be intractable targets for conventional drugs. Moreover, it is likely that many bioportides achieve a biological influence by a dominant-negative action upon protein-proitein interactions (PPIs).
Your next task is to choose a protein or a PPI interface that might be a useful target for therapeutic manipulation. There are of course many possibilities and I am keen for you to choose your own! Now imgaine you are tasked by a pharmaceutical company to develop a strategy, employing CPPs/Bioportides, to manipulate that intracellular target. You will need to produde a report to pass on to the peptide synthesis team highlighting sequences of peptides that can be screened as potential therapeutics. These might be inert CPPs attached to a bioactive peptide seuquence or a bioportide that is predicted to be both cell penetrant and bioactive. Your project write-up is essentially that report. The results section will contain the sequences and stratagies that you design to influence the activity of your intracellular protein or process. Theoretically, I could pass on your project to next year’s students and ask them to manufacture the peptides you design.

For those of you who decide to embark upon the DRY Project, your literature review should focus on Cell Penetrating Peptides, Bioportides and Protein-Protein Interactions

Read Assignment 5 guidelines attached and notes below. I already chose the location (please see attached). I already did research part of ESRI Business Analyst Online. If I am missing anything please let me know.

I’d like to make a few suggestions on Assignment 5 when you work on it:

1. Have more specific details by looking at the 5-minute and 10-minute drive-time characteristics. You can even look at the characteristics for the 5/10/15 minute walk time, depending on the nature and target market of your development.

2. Look at the market potential profiles compiled by ESRI Business Analyst Online to help justify your market feasibility analysis.

3. Look at the tapestry segmentation profiles compiled by ESRI Business Analyst when conducting the market feasibility analysis.

4. Use the HUD excel models for financial analysis of your project. Then calculate the NPV, IRR, and profitability indices to further justify financial feasibility.

5. Describe the site, such as location, zoning, size, etc. before you get into everything else. Some of you did not do so for your Assignment 4.

6. Fully take advantage of the data reports, maps, and charts provided by ESRI Business Analyst.

7. Don’t simply copy and paste long tables from ESRI BAO into your report. Some long tables are not readable and have excessive information. The tables can be downloaded as Excel files. Choose part of the data and create tables or charts of your own.

8. Make sure your maps and charts are readable.

literature review
CPP/Bioportide technologies have the capcity to reach intracellular sites that may be intractable targets for conventional drugs. Moreover, it is likely that many bioportides achieve a biological influence by a dominant-negative action upon protein-proitein interactions (PPIs).
Your next task is to choose a protein or a PPI interface that might be a useful target for therapeutic manipulation. There are of course many possibilities and I am keen for you to choose your own! Now imgaine you are tasked by a pharmaceutical company to develop a strategy, employing CPPs/Bioportides, to manipulate that intracellular target. You will need to produde a report to pass on to the peptide synthesis team highlighting sequences of peptides that can be screened as potential therapeutics. These might be inert CPPs attached to a bioactive peptide seuquence or a bioportide that is predicted to be both cell penetrant and bioactive. Your project write-up is essentially that report. The results section will contain the sequences and stratagies that you design to influence the activity of your intracellular protein or process. Theoretically, I could pass on your project to next year’s students and ask them to manufacture the peptides you design.

For those of you who decide to embark upon the DRY Project, your literature review should focus on Cell Penetrating Peptides, Bioportides and Protein-Protein Interactions

You are to assume the role of chief executive of a Destination Management Company of your choice. You are to produce a pre-feasibility study of a new build convention centre for your chosen destination. Your pre-feasibility study would form part of a bid to potential funding partners, in which you are to make appropriate recommendations around the existing events environment, economic situation, funding and operational issues for your proposal.

In addition, students will be awarded additional credit where:
– Students consider the macro environment in which Convention Centres operate.
– Students consider the key stakeholders for the proposal with strategic partners where appropriate
– The overall rationale for the project with specific aims and objectives for the Convention Centre are given
– An appreciation of the economic, political and social implications on the host region is evident
– Consideration is given to the financial viability of the project
– Operational decision making is considered to include project management approaches, and human resources implications
– An appreciation of underpinning research is made evident

1.Critically assess the dynamic nature of the Global Meetings and Events Environment.
3. Critically analyse the economic considerations and funding for large scale events projects.
4. Critically assess the operational management requirements for large scale event projects.

Please use the grading rubric to create an outline of your assignment. Each section of the rubric should be a section of your final paper and could become the headings. Your assignment will be graded based on each element of the rubric. Compare each section of your paper with the rubric to ensure all elements are covered. Then, include an introduction and conclusion to tie the paper together. If you have any questions regarding the assignment please contact your instructor using the Course Help forum.
Do you have additional questions about this assignment or would you like more guidance?   Professor IQTM may be able to help you.  Type in any questions you may have about the assignment or select the questions that are present.  Keep in mind that if Mary doesn’t know the answer she will become smarter with each question she is asked and your instructor will be able to help you if Mary cannot.
Analyze the position statement from the International Council of Nurses chosen in week 1. This position statement is the foundation for this final project.
In a 12 to 15 slide PowerPoint presentation, not including the title slide and reference slide, address the following:
Present the Position Statement.
Describe why this issue is important to professional nursing practice.
Analyze at least three scholarly nursing articles related to this subject, including what the articles add to the understanding of this issue.
Describe legal and ethical implications of the issue using the ANA Code of Ethics (2001) as framework.
Summarize how this position statement can be utilized to improve the health of the population.
Use bullet points on the content slides and include speaker’s notes to discuss the content.  Remember to use APA 6th edition formatting for slide references and review the link on How to make an APA formatted PPT slide presentation.
The standard of performance required for undergraduate nursing programs is C+ (77%) or higher in all nursing courses. Students who earn a grade of less than C+ in any nursing course must repeat the course and earn at least a C+ in order to complete the program of study. If a student’s GPA falls below 2.0 he or she may be placed on academic probation.
Final Project Rubric
Competency
18 Points
12 Points
6 Points
0 Points
Total
Present the Position Statement
Presents the Position Statement
Presents the title of the Position Statement but does not include any additional information
Does not present the Position Statement
No paper submitted or content missing
/18
Describe why this issue is important to professional nursing practice
Describes why this issue is important to professional nursing practice
Superficially describes why this issue is important to professional nursing practice
Does not describe why this issue is important to professional nursing practice
No paper submitted or content missing
/18
Analyze at least three scholarly nursing articles related to this subject, including what the articles add to the understanding of this issue
Analyzes at least three scholarly nursing articles related to this subject, including what the articles add to the understanding of this issue
Analyzes at two scholarly nursing articles related to this subject, including what the articles add to the understanding of this issue
Analyzes at one scholarly nursing articles related to this subject, including what the articles add to the understanding of this issue
No paper submitted or content missing
/18
Describe legal and ethical implications of the issue using the ANA Code of Ethics (2001) as framework
Describes legal and ethical implications of the issue using the ANA Code of Ethics (2001) as framework
Describes legal or ethical implications of the issue using the ANA Code of Ethics (2001) as framework
Describes legal and ethical implications of the issue but does not use the ANA Code of Ethics (2001) as framework
No paper submitted or content missing
/18
Summarize how this position statement can be utilized to improve the health of the population
Summarizes how this position statement can be utilized to improve the health of the population
Superficially  summarizes how this position statement can be utilized to improve the health of the population
Does not summarize how this position statement can be utilized to improve the health of the population
No paper submitted or content missing
/18
Competency
2.5 Points
2 Points
1 Point
0 Points
Total
Organization
Organization excellent, ideas clear and arranged logically, transitions smooth, no flaws in logic.
Organization good; ideas usually clear and arranged in acceptable sequence; transitions usually smooth, good support
Organization minimally effective; problems in approach, sequence, support and transitions
Organization does not meet requirements
/2.5
Grammar
Grammar, punctuation, mechanics, and usage correct and idiomatic, consistent with Standard American English
Grammar, punctuation, mechanics, and usage good mostly consistent with Standard American English; errors do not interfere with meaning or understanding
Grammar, punctuation, mechanics and usage distracting  and often interfere with meaning or understanding
Grammar, punctuation, mechanics, and usage interfere with understanding
/2.5
APA Format
Demonstrates competent use of mechanics and APA
Minimal APA errors
Many APA errors
Complete lack of understanding
/2.5
References
References are relevant, authoritative and contemporary
Adequate references
Minimal use of appropriate references
Poor use and/or selection of references not relevant
/2.5
TOTAL
/100
Academic integrity: Sources not cited and/or word-for-word (verbatim) content used from another source without the use of quotation marks earns a 0 for the paper.

Paper Topic

Marjorie Shostak’s ethnography, Nisa: The Life and Words of a !Kung Woman, is guided by the narrative of the stories of Nisa’s life. About her stories, Nisa tells Shostak, “I’ll tell you another one now. I’ll break open the story and tell you what is there. Then, like the others that have fallen out onto the sand, I will finish with it, and the wind will take it away.” (36)

In this course, we learn about the stories of many people of many different cultures. At first glance, some of their stories may seem completely different from the events of our own lives. Upon closer examination, we can find many themes that run through the lives of the !Kung also run through our own.

Another major theme of our course is cultural adaptation. From your new anthropologist’s perspective, you should be able to examine a cultural practice in an objective way. For example, does the !Kung practice of sharing meat hurt or enhance their survival as a group? Does it support their health or well-being? A practice can be evaluated in this way even if it is not part of our own cultural norms.

PAPER TOPIC

Compare and contrast the aspects of !Kung life with your own. Choose at least three aspects to discuss. These may be rites of passage (such as birth, marriage, divorce, death) or other aspects of !Kung life (choosing a partner, healing the sick, securing food for consumption), etc.

For each aspect, first describe the practice in !Kung life. (You may rely solely on the Shostak text for this section, or use one of the required outside scholarly sources.)

Second, compare and/or contrast it with the practice in your own culture. Note the similarities or differences. (You may bring in outside scholarly sources in this section.)

Third, evaluate the practice based on its adaptability for the !Kung. Do you think the way the !Kung behave in this situation is adaptive for their health and well-being (even if it is unlike the way we behave in this situation)? Does it aid their success as a group? Give your opinion (analysis) based on evidence from the text or from scholarly sources.

PAPER REQUIREMENTS

Your paper must be 4-5 pages long, double-spaced with 0.8” to 1.0” margins with 10 or 12 point traditional font. The minimum length is 4 full pages. Please provide a References page at the end of the document using APA formatting.

Two scholarly sources are required for this assignment beyond the Shostak text. Scholarly sources come from academic journals or books from a university press. You will need to use the library’s databases (such as ProQuest) or physically check out books from the library to meet this requirement. Please see the TIPS FOR FINDING SCHOLARLY SOURCES handout in the Assignments section of the course.

Please use citations (or quotes) to support your arguments. To cite passages from a text, put quotation marks around a passage followed immediately by the author’s last name and page number in parentheses. Quotes should be brief, under four lines.

For example:

“My heart was so happy I moved around like a little dog, wagging my tail and running around. Really! I was so happy, I shouted out what I saw: ‘The rainy season has come today! Yea! Yea!'”(Shostak: 89)

If you must use a longer quote than four lines, eliminate the quotation marks, single space, and indent the entire quote several tabs from the left margin.

Be sure to explain why you are using a particular quote. A quote by itself does not prove a point. It only provides evidence for your argument. You must make an argument preceding or following the quote.

Using other people’s words constitutes plagiarism. Provide quotes and a reference including the author’s name, title and page number for more than three words in a row that are not your own. Please use APA formatting to provide a reference for the Nisa text and any other texts that you may have used at the end of the document.

Please spell-check your paper (check for typos, mistakes, etc.), organize it into indented paragraphs, and write in a clear and simple style.

1.You can decide the Essay title, Research Question , Essay type e.g Cause and effect, Definition, Comparison and contrast, Expository, Process, Classification – Division? , Purpose and reader.

2. The paper should three main points and a good thesis statement(please underline it)

3. The paper should include the four essay that I will upload. Must use these essays as references and include in the paper.

4. It is very important to paraphrase the following sentences well, then underline and use it in the essay.

Working holiday:

“But the nature of working holidays is different from that of short-term travel; working holiday programs involve different work content and relevant issues of cultural adaption, where consumers are often engaged in a more complicated decision-making processes.” (p. 96)

From: Yu-Ting Huang and Chin-Shang Hsu, (2013) “ A Confirmation of the Behavioral Intention of College Students in Recreational Sports Related Departments in Taiwan towards Overseas Working Holidays Based on the Theory of Planned Behavior”, The Journal of Human Resource and Adult Learning, 9 (2): 95-104

Bennett and Royle argue that all literature concerns itself with the secret–not only the revelation of a secret, but the idea of literature as “resistant to being read” (An Intro to Literature 275). “Adventure of the Dancing Men” by British author Sir Arthur Conan Doyle; “Murder in the Rue Morgue” Short story by Edgar Allan Poe. Discuss the ways in which the characters and/or the narrative rely on secrets as an important part of their narrative or generic structure. HINT: Does EVERYTHING get explained at the end of the story? Why/not? How does this confirm/undermine our understanding of the way the ‘real’ world works?

– Use 12 Times New roman
_ use the criteria sheet as a guide to your work as it it vital in completion of this peice of assessment successfully.
– make the argument your target to make the focus strong and specific to support the argument.

use direct quotes from the two main sources to illustrate your point in addition to jornal articles and books to support the argument. all of them should be 12 sources so 2 primary and 10 secondary sources.

do not use any web sources. as this will result in penalty.
– do not shift outside the main points to increase the focus in the argument.

Postmortem Audit Review of Projects

Postmortem Guidelines (“Major Ground Rules”)

Do not get back at people – make it clear, postmortem is not for getting back at people or finger pointing
Do not be oversensitive – check your ego at the door; be humble
Do not attack anyone – focus on the problem, not the people
Do not forget facts – what gets measured, gets improved
Do not write a postmortem book – people in future won’t read long reports
Discussion Topic:

General Construction Company has a contract to build three lower-income apartment buildings for the city of Santa Fe, New Mexico. During the construction of the first building, the Project Manager formed an auditing team to audit the construction process for each building. He asked the team to develop a list of minimum requirements for the projects and use this as a baseline in the audit.

While reviewing the contract documents, one of the audit team members found a discrepancy between the contract minimum requirements and the City’s minimum requirements. Based on his findings, he has told the project manager that he has decided to contact the City Administrator and discuss the problem.

Required:

Review the Postmortem Guidelines, a.k.a. “Major Ground Rules” outlined above, for preparing information inputs for a postmortem audit review of projects. As the Project Manager, discuss how you would handle the situation in the General Construction Company above.
In addition to your response above, respond to the discussions of at least two other students’ postings.
[Source: Samuel Mantel, Jack Meredith, Scott Shafer, and Margaret Sutton, Project Management in Practice, 4thEdition, John Wiley and Sons, Inc., 2011]

Assignment is four parts. Please label each part of the assignment Part 1, Part 2, Part 3, and Part 4 in the document, and insert a page break after each part. Please submit as one document.

Assignment requires the use of MS Project or similar software.

Part 1: Develop an in-depth schedule for your initial project based on the Work Breakdown Structure. Please refer to the Integrated Project. Include:

1. An activity precedence diagram 2. An activity duration table 3. A network diagram and Gantt charts

Part 2: Please complete Case Study 10.2, “Project Scheduling at Blanque Check Construction” respond to the questions for discussion. Please make sure that each question is answered thoroughly; minimum of 200 words for each case study question.

Part 3: Develop the network activity chart and identify the critical path for a project based on the information provided in the Gantt Chart Activity document.

1. Draw the activity network as a Gantt chart. 2. What is the expected duration of the project?

Part 4: Consider the project with the information provided in the Project Activity Network document.

1. Construct the project activity network using AON methodology and label each node. 2. Identify the critical path and other paths through the network.